Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 9/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 3/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19443193 | 0.71 | DGAT1 (0.43) | MAPK14DGAT1 | |
| SCHEMBL18746440 | 0.69 | DGAT1 (0.40) | MAPK14DGAT1AOC3 | |
| SCHEMBL17211815 | 0.67 | ALDH1A1 (0.35) | MAPK14DGAT1AOC3ALDH1A1GAA | |
| SCHEMBL17195437 | 0.66 | DGAT1 (0.49) | DGAT1ALDH1A1 | |
| SCHEMBL15742518 | 0.66 | DGAT1 (0.47) | DGAT1AOC3 | |
| SCHEMBL14061891 | 0.65 | DGAT1 (0.48) | DGAT1 | |
| SCHEMBL14061631 | 0.64 | SMN1; SMN2 (0.49) | DGAT1AOC3 | |
| SCHEMBL14061811 | 0.64 | DGAT1 (0.56) | DGAT1 | |
| SCHEMBL17211843 | 0.63 | DGAT1 (0.55) | DGAT1ALDH1A1 | |
| SCHEMBL17195444 | 0.63 | DGAT1 (0.55) | DGAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2916839-B1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-10-11 | — | — | EP | disclosed |