Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19437906 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19449434 | 0.87 | HPGDS (0.46) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL19438151 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19449437 | 0.83 | MAPT (0.43) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19449408 | 0.82 | CSNK1E (0.38) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19449388 | 0.81 | HSD17B10 (0.40) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19681732 | 0.81 | MKNK1 (0.44) | ALDH1A1KDM4EHSD17B10MAPK1APOBEC3A | |
| SCHEMBL19449288 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19449643 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL19449634 | 0.79 | MEN1 (0.38) | ALDH1A1KDM4EHPGDHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176961-A1 | IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-10-12 | — | — | WO | disclosed |