Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19437816 | 0.90 | PIN1 (0.50) | MAP4K2HSD17B10KDM4ELMNAADORA1 | |
| SCHEMBL19437974 | 0.86 | KDM4E (0.50) | HSD17B10KDM4EADORA1ADORA2ACYP3A4 | |
| SCHEMBL19449569 | 0.85 | PDGFRB (0.44) | MAP4K2HSD17B10KDM4EADORA1ADORA3 | |
| SCHEMBL19449434 | 0.84 | HPGDS (0.46) | HSD17B10KDM4EADORA1ADORA2AATR | |
| SCHEMBL19449408 | 0.83 | CSNK1E (0.38) | IKBKBMAP4K2HSD17B10KDM4EADORA1 | |
| SCHEMBL19449573 | 0.82 | TP53 (0.47) | HSD17B10KDM4EADORA1ADORA2ACYP3A4 | |
| SCHEMBL19438041 | 0.82 | TYRO3 (0.42) | MAP4K2HSD17B10KDM4EADORA1ADORA3 | |
| SCHEMBL19438266 | 0.82 | HSD17B10 (0.45) | MAP4K2HSD17B10KDM4ELMNAADORA1 | |
| SCHEMBL19449633 | 0.81 | TGFBR1 (0.43) | — | |
| SCHEMBL19681732 | 0.81 | MKNK1 (0.44) | IKBKBIRAK4HSD17B10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176961-A1 | IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-10-12 | — | — | WO | disclosed |