SCHEMBL1945082

SCHEMBL1945082

COc1ccccc1-c1c2nc(cc3ccc(cc4nc(cc5ccc1[nH]5)C=C4)[nH]3)C=C2

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.54
▸ STAT1 P42224 1/20 0.54
▸ ALDH1A1 P00352 4/20 0.43
▸ HPGD P15428 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ PDE5A O76074 4/20 0.39
▸ AURKA O14965 1/20 0.39
▸ DCUN1D1 Q96GG9 2/20 0.37
▸ GAA P10253 1/20 0.36
▸ MAP2 P11137 1/20 0.36
▸ SLC2A1 P11166 1/20 0.36
▸ AMY1A P0DUB6 1/20 0.36
▸ ALPL P05186 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27646298 0.86 STAT3 (0.49) STAT3STAT1ALDH1A1HPGDSMN1; SMN2
SCHEMBL27579991 0.84 STAT3 (0.58) STAT3STAT1ALDH1A1HPGDSMN1; SMN2
SCHEMBL2800284 0.83 STAT3 (0.46) STAT3STAT1ALDH1A1HPGDSMN1; SMN2
SCHEMBL27840009 0.83 STAT3 (0.46) STAT3STAT1ALDH1A1HPGDSMN1; SMN2
SCHEMBL4410598 0.83 STAT3 (0.49) STAT3STAT1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL6026572 0.82 STAT3 (0.39) STAT3STAT1ALDH1A1HPGDSMN1; SMN2
SCHEMBL3276862 0.82 ALDH1A1 (0.43) STAT3STAT1ALDH1A1HPGDSMN1; SMN2
SCHEMBL825274 0.82 STAT3 (0.48) STAT3STAT1MAPT
SCHEMBL311440 0.81 STAT3 (0.55) STAT3STAT1
SCHEMBL6026570 0.81 ALDH1A1 (0.50) ALDH1A1HPGDSMN1; SMN2KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292409-A Electrolytically generating superoxide ion under protective layer of ion exchange material CAPE COD RESEARCH, INC. (US) 1994-03-08 — — US claimed
CN-119530876-A Composite catalyst, electrode carrying composite catalyst, and preparation method and application of electrode 中国石油化工股份有限公司 2025-02-28 — — CN disclosed
CN-107195935-A CIHT dynamical systems 辉光能源公司 2017-09-22 — — CN disclosed
US-20110136774-A1 Anti-Apoptotic Benzodiazepine Receptor Ligand Inhibitors MALFROY-CAMINE BERNARD 2011-06-09 — — US disclosed
US-20100120738-A1 ANTI-APOPTOTIC BENZODIAZEPINE RECEPTOR LIGAND INHIBITORS MALFROY-CAMINE BERNARD 2010-05-13 — — US disclosed
WO-2008033444-A2 ANTI-APOPTOTIC BENZODIAZEPINE RECEPTOR LIGAND INHIBITORS EUKARION, INC. (US) 2008-03-20 — — WO disclosed
US-4255273-A COMPRISING A WATER-SOLUBLE PHOTOACTIVATOR AND A CATIONIC SUBSTANCE THE PROCTER & GAMBLE COMPANY (US) 1981-03-10 — — US disclosed
EP-0003371-A1 Composition containing a cationic substance and a photoactivator for improved washing and bleaching of fabrics THE PROCTER & GAMBLE COMPANY (US) 1979-08-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100120738-A1 ANTI-APOPTOTIC BENZODIAZEPINE RECEPTOR LIGAND INHIBITORS AIFM1, BAK1, BAX STAT3 2102/4885STAT1 3428/4885ALDH1A1 2737/4885
US-20110136774-A1 Anti-Apoptotic Benzodiazepine Receptor Ligand Inhibitors AIFM1, BAK1, BAX STAT3 2102/4885STAT1 3428/4885ALDH1A1 2737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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