Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13355126 | 0.85 | CYP19A1 (0.50) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL13322651 | 0.75 | CYP19A1 (0.44) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL6578753 | 0.74 | CYP19A1 (0.58) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL1135841 | 0.73 | DAO (0.50) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL434941 | 0.73 | CYP19A1 (0.56) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL1135497 | 0.73 | DAO (0.56) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL31426151 | 0.73 | NQO2 (0.53) | CYP19A1NQO2ALDH1A1KDM4EMAPT | |
| SCHEMBL22271826 | 0.73 | CYP19A1 (0.60) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL28691180 | 0.73 | KDM4E (0.63) | CYP19A1NQO2ALDH1A1KDM4EHPGD | |
| SCHEMBL1135509 | 0.73 | CYP19A1 (0.45) | CYP19A1NQO2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285786-B1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-09 | — | — | EP | claimed |
| US-8329698-B2 | Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-12-11 | — | — | US | claimed |
| US-20110130404-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-06-02 | — | — | US | claimed |
| US-8674097-B2 | Quinoxalinedione derivatives useful as activators of AMPK-activated protein kinase | MERCK PATENT GMBH (DE) | 2014-03-18 | — | — | US | disclosed |
| EP-2285786-B1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-20120322806-A1 | QUINOXALINEDIONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-20 | — | — | US | disclosed |
| US-8329698-B2 | Quinoxalinedione derivatives which are activators of AMPK-activated protein kinase | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130404-A1 | QUINOXALINEDIONE DERIVATIVES | GLP1R, GPR119, NDUFS3 | CYP19A1 213/4885NQO2 7/4885ALDH1A1 829/4885 |
| US-20120322806-A1 | QUINOXALINEDIONE DERIVATIVES | GLP1R, GPR119, NDUFS3 | CYP19A1 213/4885NQO2 7/4885ALDH1A1 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.