SCHEMBL31426151

SCHEMBL31426151

COc1cccc2c1cc(C)c(=O)n2C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 4/20 0.53
CYP19A1 P11511 2/20 0.53
MAPT P10636 3/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
POLB P06746 1/20 0.47
ALOX15 P16050 1/20 0.47
RECQL P46063 1/20 0.47
BRD1 O95696 2/20 0.46
BRPF1 P55201 2/20 0.46
BRD4 O60885 2/20 0.46
KDM4E B2RXH2 3/20 0.45
ALDH1A1 P00352 1/20 0.45
BRPF3 Q9ULD4 1/20 0.44
TSHR P16473 1/20 0.41
KDM1A O60341 1/20 0.41
BRD2 P25440 1/20 0.41
BRD9 Q9H8M2 1/20 0.41
BRD7 Q9NPI1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL434299 0.80 CYP19A1 (0.46) NQO2CYP19A1MAPTL3MBTL1MEN1
SCHEMBL11983222 0.78 KDM4E (0.45) NQO2CYP19A1MAPTPOLBKDM4E
SCHEMBL26547562 0.77 KDM4E (0.50) NQO2MAPTMEN1KMT2ABRD1
SCHEMBL4717380 0.77 BRPF1 (0.50) NQO2MAPTMEN1KMT2APOLB
SCHEMBL30480838 0.77 KDM4E (0.50) NQO2MAPTMEN1KMT2ABRD1
SCHEMBL26547628 0.76 MEN1 (0.43) NQO2CYP19A1MAPTL3MBTL1MEN1
SCHEMBL29471200 0.76 MEN1 (0.43) NQO2CYP19A1MAPTL3MBTL1MEN1
SCHEMBL17576252 0.75 KDM4E (0.49) NQO2CYP19A1MAPTL3MBTL1MEN1
SCHEMBL434941 0.74 CYP19A1 (0.56) NQO2CYP19A1MAPTL3MBTL1MEN1
SCHEMBL19276931 0.74 PKM (0.44) NQO2MAPTMEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025049994-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2025-03-06 WO disclosed