Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 6/20 | 0.59 |
| ▸ | TYR | P14679 | 2/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848654 | 0.84 | TYR (0.57) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL10849192 | 0.80 | TYR (0.56) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL5695419 | 0.80 | MAPT (0.64) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL5695458 | 0.80 | MAPT (0.64) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL23094590 | 0.74 | CGAS (1.00) | CGASTYRSIRT1MAPTKMT2A | |
| SCHEMBL22625308 | 0.74 | MAPT (0.61) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL5695444 | 0.74 | TYR (0.74) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL5695416 | 0.74 | TYR (0.74) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL153106 | 0.74 | MDM2 (0.54) | TYRMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL153105 | 0.74 | MDM2 (0.54) | TYRMAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176812-A1 | cGAS ANTAGONIST COMPOUNDS | IMMUNE SENSOR, LLC (US) | 2017-10-12 | — | — | WO | disclosed |