Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | ATM | Q13315 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | GAA | P10253 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713217 | 0.95 | MAPT (0.64) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL1565331 | 0.89 | MAPT (0.69) | MAPTATMKDM4EGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL4692433 | 0.87 | MAPT (0.67) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL1947188 | 0.82 | MAPT (0.49) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL8579776 | 0.81 | MAPT (0.49) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL1546553 | 0.81 | MAPT (0.67) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL1943360 | 0.81 | MAPT (0.47) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL1947204 | 0.80 | MAPT (0.63) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL562514 | 0.78 | MAPK10 (0.51) | MAPTATMKDM4EGAAALDH1A1 | |
| SCHEMBL1947280 | 0.78 | MAPT (0.48) | MAPTATMKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072574-B | 5, 6-diamino-1, 3-dialkyl substituted uracil and its preparation method | 广东工业大学 | 2023-03-14 | — | — | CN | disclosed |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-01-18 | — | — | US | disclosed |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-01-18 | — | — | US | disclosed |
| EP-3397640-B1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INST NAT SANTE RECH MED (FR) | 2021-08-04 | — | — | EP | disclosed |
| EP-3397640-B1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INST NAT SANTE RECH MED (FR) | 2021-08-04 | — | — | EP | disclosed |
| CN-111072574-A | 5, 6-diamino-1, 3-dialkyl substituted uracil and its preparation method | 广东工业大学 | 2020-04-28 | — | — | CN | disclosed |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-26 | — | — | US | disclosed |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-26 | — | — | US | disclosed |
| EP-3397640-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2018-11-07 | — | — | EP | disclosed |
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |
| US-20030139428-A1 | A2B adenosine receptor antagonists | GILEAD SCIENCES, INC. | 2003-07-24 | — | — | US | disclosed |
| US-20030060627-A1 | 8-Phenyl-6, 9-dihydro-[1,2,4] triazolo[3,4-i]purin-5-one derivatives | ALMIRALL PRODESFARMA, S.A. (ES) | 2003-03-27 | — | — | US | disclosed |
| EP-1198464-A1 | 8-PHENYL-6,9-DIHYDRO- 1,2,4]TRIAZOLO 3,4- i i /i ]PURIN-5-ONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001007441-A1 | 8-PHENYL-6,9-DIHYDRO-[1,2,4]TRIAZOLO[3,4-i]PURIN-5-ONE DERIVATIVES | ALMIRALL PRODESFARMA S.A. (ES) | 2001-02-01 | — | — | WO | disclosed |
| US-4644001-A | BRONCHODILATOR, CARDIOTONIC AGENTS | AKTIEBOLAGET DRACO (SE) | 1987-02-17 | — | — | US | disclosed |
| US-4581451-A | ALKYLATION AND CYCLIZATION OF A URACIL COMPOUND | NESTEC S.A. (CH) | 1986-04-08 | — | — | US | disclosed |
| US-4548818-A | Composition and methods for the treatment of chronic obstructive airway disease and cardiac disease using 3-alkylxanthines | AKTEBOLAGET DRACO, A COMPANY OF SWEDEN (SE) | 1985-10-22 | — | — | US | disclosed |
| EP-0039780-B1 | DI- OR TRISUBSTITUTED XANTHINES WITH NEUROLEPTIC ACTIVITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1985-04-10 | — | — | EP | disclosed |
| US-4469698-A | SEDATIVES, TRANQUILIZERS | SOCIETE D'ASSISTANCE TECHNIQUE POUR PRODUITS NESTLE S.A. (CH) | 1984-09-04 | — | — | US | disclosed |
| EP-0039780-A1 | Di- or trisubstituted xanthines with neuroleptic activity, process for their preparation and pharmaceutical preparations containing them | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1981-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060627-A1 | 8-Phenyl-6, 9-dihydro-[1,2,4] triazolo[3,4-i]purin-5-one derivatives | HYOU1, CHN2, PURB | MAPT 4809/4885ATM 4633/4885KDM4E 4355/4885 |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | BET1, BRD4, BRD3 | MAPT 2558/4885ATM 2292/4885KDM4E 276/4885 |
| US-20030139428-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA1 | MAPT 4828/4885ATM 2334/4885KDM4E 4096/4885 |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | BET1, BRD4, BRD3 | MAPT 2558/4885ATM 2292/4885KDM4E 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.