CHN2

Beta-chimaerin · P52757 · CHN2 on Sugi Atlas →

104 patent compounds predicted against CHN2, 69 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29648523	1.00	1/20
SCHEMBL16562342	0.81	1/20
SCHEMBL30139090	0.81	1/20
SCHEMBL22275557	0.72	1/20
SCHEMBL13798724	0.70	1/20
SCHEMBL13798725	0.66	1/20
SCHEMBL21026497	0.65	1/20
Valrubicin (SCHEMBL12824)	0.65	1/20
Valrubicin (SCHEMBL12825)	0.65	1/20
Valrubicin (SCHEMBL1652790)	0.65	1/20
Valrubicin (SCHEMBL4053249)	0.65	1/20
Valrubicin (SCHEMBL12556870)	0.65	1/20
Valrubicin (SCHEMBL15372178)	0.65	1/20
Valrubicin (SCHEMBL20541443)	0.65	1/20
Valrubicin (SCHEMBL29418969)	0.65	1/20
SCHEMBL14341788	0.64	1/20
SCHEMBL19325422	0.64	1/20
Valrubicin (SCHEMBL28183048)	0.64	1/20
SCHEMBL13394009	0.64	1/20
Valrubicin (SCHEMBL22463650)	0.64	1/20

Clinical trials — most relevant to CHN2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of BIIB111 for the Treatment of Choroideremia	PHASE3	COMPLETED
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors	PHASE1	COMPLETED
CHAPTER: Clonal Haematopoiesis Assessment: Prevention, Treatment and Research	nan	RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)	nan	RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
Corpus Callosum Agenesis and Intellectual Disability	nan	COMPLETED
Genotype/Phenotype Correlation With Focus on Lung Function in Primary Ciliary Dyskinesia (PCD)	nan	UNKNOWN
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Long-Term Follow-Up of Survivors of Pediatric Cushing Disease	nan	RECRUITING
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)	nan	RECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia	nan	COMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease	nan	COMPLETED
Immune Cell Response to Stimuli	nan	RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
The Genetic Characterization of Dementia	nan	COMPLETED
Natural History of Neuronal Ceroid Lipofuscinosis, Batten's CLN6 Diseae	nan	ACTIVE_NOT_RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CHN2 binder may also engage these)

Protein	Name	Similarity
P15882	—	0.998	P15882 →
Q91V57	—	0.995	Q91V57 →
Q9R0C8	—	0.976	Q9R0C8 →
Q9UKW4	—	0.973	Q9UKW4 →
B4F7E7	—	0.970	B4F7E7 →
P52735	—	0.970	P52735 →
MAP4K5	Mitogen-activated protein kinase kinase kinase kinase 5	0.969	landscape →
Q8BPM2	—	0.969	Q8BPM2 →
VAV1	Proto-oncogene vav	0.968	landscape →
Q9H8V3	—	0.968	Q9H8V3 →
P97696	—	0.967	P97696 →
Q60992	—	0.967	Q60992 →
RAPGEF4	Rap guanine nucleotide exchange factor 4	0.967	landscape →
Q76MZ1	—	0.967	Q76MZ1 →
B2RQE8	—	0.966	B2RQE8 →
Q9WU22	—	0.966	Q9WU22 →
PTPN4	Tyrosine-protein phosphatase non-receptor type 4	0.966	landscape →
A2APV2	—	0.966	A2APV2 →
P54100	—	0.966	P54100 →
Q08DN7	—	0.965	Q08DN7 →
A0A3Q1LSX9	—	0.965	A0A3Q1LSX9 →
O08967	—	0.965	O08967 →
Q07139	—	0.965	Q07139 →
Q5M7Y0	—	0.965	Q5M7Y0 →
Q15438	—	0.964	Q15438 →
Q92796	—	0.964	Q92796 →
B5DFQ4	—	0.964	B5DFQ4 →
P25911	—	0.964	P25911 →
Q62844	—	0.964	Q62844 →
PRKCA	Protein kinase C alpha type	0.964	landscape →