Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456111 | 0.85 | BRD4 (0.37) | BRD4 | |
| SCHEMBL21649796 | 0.84 | BRD4 (0.48) | BRD4 | |
| SCHEMBL19456136 | 0.83 | ITGB3 (0.46) | BRD4ITGB3ITGA2BROCK2 | |
| SCHEMBL19456220 | 0.83 | BRD4 (0.57) | BRD4 | |
| SCHEMBL21649801 | 0.82 | BRD4 (0.50) | BRD4 | |
| SCHEMBL19456155 | 0.81 | BRD4 (0.45) | BRD4 | |
| SCHEMBL19456311 | 0.81 | BRD4 (0.44) | BRD4NAMPT | |
| SCHEMBL19456341 | 0.81 | BRD4 (0.40) | BRD4 | |
| SCHEMBL19456232 | 0.79 | BRD4 (0.54) | BRD4 | |
| SCHEMBL19456213 | 0.79 | BRD4 (0.43) | BRD4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |