Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945681 | 0.99 | RXFP1 (0.57) | RXFP1ACKR3KDM4EMAPTPOLB | |
| SCHEMBL1946018 | 0.89 | HDAC8 (0.46) | RXFP1ACKR3KDM4EMAPTPOLB | |
| SCHEMBL1946478 | 0.88 | MEN1 (0.50) | RXFP1ACKR3KDM4EMAPTPOLB | |
| SCHEMBL6360616 | 0.77 | GSK3B (0.53) | RXFP1KDM4EMAPTPOLBHPGD | |
| SCHEMBL7826262 | 0.75 | ALDH1A1 (0.49) | RXFP1KDM4EMAPTPOLBHPGD | |
| SCHEMBL27547515 | 0.75 | GAA (0.54) | RXFP1KDM4EMAPTPOLBHPGD | |
| SCHEMBL1949315 | 0.75 | ACKR3 (0.76) | RXFP1ACKR3KDM4EMAPTPOLB | |
| SCHEMBL5227048 | 0.74 | HDAC3 (0.50) | RXFP1KDM4EMAPTHPGDGAA | |
| SCHEMBL1587164 | 0.73 | KDM4E (0.51) | RXFP1KDM4EMAPTPOLBHPGD | |
| SCHEMBL12124267 | 0.73 | POLB (0.65) | RXFP1KDM4EMAPTPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| WO-2009137081-A2 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009137081-A2 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, MDH1 | RXFP1 4839/4885ACKR3 3794/4885KDM4E 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.