Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945855 | 0.93 | CYP19A1 (0.54) | MAPTKMT2AMEN1ALDH1A1CYP19A1 | |
| SCHEMBL1948486 | 0.87 | MAPT (0.49) | MAPTKMT2AMEN1CYP19A1CYP1A2 | |
| SCHEMBL1945694 | 0.86 | CYP19A1 (0.51) | MAPTKMT2AMEN1CYP19A1CYP1A2 | |
| SCHEMBL12563281 | 0.84 | ERCC5 (0.46) | MAPTKMT2AMEN1CYP19A1CYP1A2 | |
| SCHEMBL1945862 | 0.84 | CYP19A1 (0.51) | MAPTKMT2AMEN1ALDH1A1CYP19A1 | |
| SCHEMBL1948109 | 0.84 | ALDH1A1 (0.54) | MAPTKMT2AMEN1ALDH1A1CYP19A1 | |
| SCHEMBL1946611 | 0.83 | CYP19A1 (0.47) | MAPTKMT2AMEN1ALDH1A1CYP19A1 | |
| SCHEMBL2530043 | 0.80 | CNR1 (0.54) | MAPTKMT2AMEN1ALDH1A1CYP19A1 | |
| SCHEMBL1949067 | 0.79 | KDM1A (0.52) | MAPTALDH1A1CYP19A1HTTCA1 | |
| SCHEMBL1946246 | 0.76 | HSD17B1 (0.45) | CYP19A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2011-06-02 | — | — | US | disclosed |
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2011-06-02 | — | — | US | disclosed |
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2011-06-02 | — | — | US | disclosed |
| CN-101052627-A | Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases | ASTRAZENECA AB (SE) | 2007-10-10 | — | — | CN | disclosed |
| EP-1807405-A1 | NOVEL SULPHONAMIDE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006046914-A1 | NOVEL SULPHONAMIDE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | NR3C1, NR3C2, NR5A1 | MAPT 3552/4885KMT2A 3457/4885MEN1 4498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.