Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946681 | 0.85 | RAB9A (0.70) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL27937992 | 0.83 | POLB (0.65) | ALDH1A1MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL1504213 | 0.76 | ALDH1A1 (1.00) | ALDH1A1KDM4ETSHRMAOB | |
| SCHEMBL5191884 | 0.76 | ALDH1A1 (0.77) | ALDH1A1KDM4ETSHRRAB9ANPC1 | |
| SCHEMBL7320703 | 0.76 | PRKDC (0.68) | PRKDC | |
| SCHEMBL1943579 | 0.74 | RAB9A (0.69) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1944044 | 0.73 | RAB9A (0.70) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5584787 | 0.72 | RAB9A (0.53) | ALDH1A1MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL6956271 | 0.72 | ALDH1A1 (0.69) | ALDH1A1KDM4ETSHRRAB9ANPC1 | |
| SCHEMBL20886734 | 0.72 | KMT2A (0.50) | ALDH1A1MEN1KMT2AKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304416-B2 | Chromenone derivatives | MERCK PATENT GMBH (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20110136830-A1 | CHROMENONE DERIVATIVES | MUJICA-FERNAUD TERESA | 2011-06-09 | — | — | US | disclosed |
| US-20080146589-A1 | Tyrosine kinase inhibitors; antitumor agents; food supplements; for treating non-hyperproliferative diseases; signal transduction; oxidative stress; neurodegenerative diseases | MUJICA-FERNAUD TERESA | 2008-06-19 | — | — | US | disclosed |
| US-7378421-B2 | Chromenone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-05-27 | — | — | US | disclosed |
| EP-1473293-B1 | Chromenon derivatives | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | EP | disclosed |
| US-20040220182-A1 | Chromenone derivatives | MERCK PATENT GMBH (DE) | 2004-11-04 | — | — | US | disclosed |
| EP-1473293-A1 | Chromenon derivatives | MERCK PATENT GmbH (DE) | 2004-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220182-A1 | Chromenone derivatives | RAF1, BRAF, ARAF | ALDH1A1 2147/4885MEN1 3281/4885KMT2A 4108/4885 |
| US-20080146589-A1 | Tyrosine kinase inhibitors; antitumor agents; food supplements; for treating non-hyperproliferative diseases; signal transduction; oxidative stress; neurodegenerative diseases | RET, BRAF, RAF1 | ALDH1A1 3352/4885MEN1 2243/4885KMT2A 3098/4885 |
| US-20110136830-A1 | CHROMENONE DERIVATIVES | RAF1, BRAF, ARAF | ALDH1A1 2511/4885MEN1 2522/4885KMT2A 4047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.