Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | PRKDC | P78527 | 2/20 | 0.58 |
| ▸ | ACE | P12821 | 1/20 | 0.58 |
| ▸ | ECE1 | P42892 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1942279 | 0.85 | POLB (0.71) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL7086091 | 0.85 | POLB (0.63) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL1946681 | 0.83 | RAB9A (0.70) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL1945801 | 0.83 | ALDH1A1 (0.60) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL18889298 | 0.81 | MAPT (0.78) | POLBLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL5584787 | 0.81 | RAB9A (0.53) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL20886734 | 0.80 | KMT2A (0.50) | POLBHTTMEN1KMT2AKDM4E | |
| SCHEMBL1941907 | 0.79 | ALDH1A1 (0.74) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL1944863 | 0.77 | RAB9A (0.70) | POLBLMNAHTTMEN1KMT2A | |
| SCHEMBL1943197 | 0.75 | ALDH1A1 (0.78) | POLBLMNAHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596948-B | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB (SE) | 2016-04-27 | — | — | CN | disclosed |
| CN-103596948-A | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB | 2014-02-19 | — | — | CN | disclosed |