Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429628 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL1096634 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL4428153 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL7035325 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Water SCHEMBL4426451 | 0.98 | GRK2 (0.55) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Water SCHEMBL7100681 | 0.98 | GRK2 (0.55) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Water SCHEMBL7100677 | 0.98 | GRK2 (0.55) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Cadaverine Tartrate SCHEMBL8195310 | 0.88 | GRK2 (0.47) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL27611853 | 0.87 | GRK2 (0.47) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Tert-Butyl Formate SCHEMBL27970139 | 0.85 | GRK2 (0.47) | GRK2CYP3A4SLC6A4SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101974604-B | Method for preparing paroxetine intermediate by enzyme resolution in ionic liquid | NANJING UNIVERSITY OF TECHNOLOGY | 2013-04-17 | — | — | CN | claimed |
| CN-101974604-A | Method for preparing paroxetine intermediate by enzyme resolution in ionic liquid | NANJING UNIVERSITY OF TECHNOLOGY | 2011-02-16 | — | — | CN | claimed |
| EP-0969002-B1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS CO LTD (JP) | 2003-08-27 | — | — | EP | claimed |
| US-6590102-B1 | Hydrogenation of 2-cyano-3-(p-fluorophenyl)glutaric acid diethyl ester in the presence of catalysts to prepare isomer mixtures of ethyl 4-(p-fluorophenyl)-6-oxo-3-piperidine -carboxylate, used as intermediates of paroxetine | ASAHI GLASS COMPANY LTD. (JP) | 2003-07-08 | — | — | US | claimed |
| US-20020028944-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. | 2002-03-07 | — | — | US | claimed |
| US-6316628-B1 | REACTING A TRANS-(.+-.)-4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE COMPOUND WITH L-TARTARIC ACID IN METHANOL, OR A MIXED SOLVENT OF METHANOL AND ISOPROPYL ALCOHOL OR ACETONE | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2001-11-13 | — | — | US | claimed |
| EP-0802185-B1 | Process for producing piperidinecarbinols | ASAHI GLASS CO LTD (JP) | 2001-10-17 | — | — | EP | claimed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | claimed |
| EP-0802185-A1 | Process for producing piperidinecarbinols | ASAHI GLASS COMPANY LTD. (JP) | 1997-10-22 | — | — | EP | claimed |
| EP-3313396-B1 | G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME | UNIV MICHIGAN REGENTS (US) | 2021-12-15 | — | — | EP | disclosed |
| US-10329283-B2 | G protein-coupled receptor kinase inhibitors and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-06-25 | — | — | US | disclosed |
| US-20180186779-A1 | G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2018-07-05 | — | — | US | disclosed |
| EP-3313396-A1 | G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of The University of Michigan (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016210403-A1 | G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-29 | — | — | WO | disclosed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998053824-A1 | NOVEL PROCESS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-03 | — | — | WO | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| EP-0802185-A1 | Process for producing piperidinecarbinols | ASAHI GLASS COMPANY LTD. (JP) | 1997-10-22 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028944-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same | TPH1, TPH2, TKT | GRK2 751/4885CYP3A4 140/4885SLC6A4 17/4885 |
| US-10329283-B2 | G protein-coupled receptor kinase inhibitors and methods for use of the same | GRK2, GRK4, GRK3 | GRK2 1/4885CYP3A4 4742/4885SLC6A4 1682/4885 |
| US-20180186779-A1 | G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME | GRK2, GRK4, GRK3 | GRK2 1/4885CYP3A4 4742/4885SLC6A4 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.