Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429628 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL1096634 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL1945968 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL7035325 | 1.00 | GRK2 (0.56) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Water SCHEMBL4426451 | 0.98 | GRK2 (0.55) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Water SCHEMBL7100681 | 0.98 | GRK2 (0.55) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Water SCHEMBL7100677 | 0.98 | GRK2 (0.55) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Cadaverine Tartrate SCHEMBL8195310 | 0.88 | GRK2 (0.47) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| SCHEMBL27611853 | 0.87 | GRK2 (0.47) | GRK2CYP3A4SLC6A4SLC6A2HTR2A | |
| Tert-Butyl Formate SCHEMBL27970139 | 0.85 | GRK2 (0.47) | GRK2CYP3A4SLC6A4SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315691-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF PAROXETINE AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2019-10-17 | — | — | US | claimed |
| EP-0812827-B1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMITOMO CHEMICAL CO (JP) | 2009-09-02 | — | — | EP | claimed |
| EP-1384711-A1 | Optical resolution of a piperidine derivative | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | claimed |
| EP-0969002-B1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS CO LTD (JP) | 2003-08-27 | — | — | EP | claimed |
| US-6610851-B1 | 1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-((3,4-methylene dioxyphenyl)oxymethyl)piperidine; reacting 4-(4-fluorophenyl)-3-hydroxymethylpiperidine with di-tert-butyl dicarbonate to form the carbamate; 3,4-methylenedioxyphenol | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-08-26 | — | — | US | claimed |
| US-20020028944-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. | 2002-03-07 | — | — | US | claimed |
| US-6316628-B1 | REACTING A TRANS-(.+-.)-4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE COMPOUND WITH L-TARTARIC ACID IN METHANOL, OR A MIXED SOLVENT OF METHANOL AND ISOPROPYL ALCOHOL OR ACETONE | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2001-11-13 | — | — | US | claimed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | claimed |
| US-5948914-A | PREPARING 4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE BY OPTICALLY RESOLVING WITH O-CHLOROTARTRANILIC ACID; CHEMICAL INTERMEDIATE FOR DRUGS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-09-07 | — | — | US | claimed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | claimed |
| US-12054484-B2 | Substituted tetrahydropyrans as CCR2 modulators | CHEMOCENTRYX, INC. (US) | 2024-08-06 | — | — | US | disclosed |
| US-20220153733-A1 | SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS | CHEMOCENTRYX, INC. | 2022-05-19 | — | — | US | disclosed |
| US-20220153733-A1 | SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS | CHEMOCENTRYX, INC. | 2022-05-19 | — | — | US | disclosed |
| EP-3297438-B1 | CCR2 MODULATORS | CHEMOCENTRYX INC (US) | 2021-10-20 | — | — | EP | disclosed |
| EP-3297438-B1 | CCR2 MODULATORS | CHEMOCENTRYX INC (US) | 2021-10-20 | — | — | EP | disclosed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| EP-0969002-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-5948914-A | PREPARING 4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE BY OPTICALLY RESOLVING WITH O-CHLOROTARTRANILIC ACID; CHEMICAL INTERMEDIATE FOR DRUGS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028944-A1 | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same | TPH1, TPH2, TKT | GRK2 751/4885CYP3A4 140/4885SLC6A4 17/4885 |
| US-12054484-B2 | Substituted tetrahydropyrans as CCR2 modulators | CCR2, CCR1, CCR5 | GRK2 87/4885CYP3A4 760/4885SLC6A4 3221/4885 |
| US-20220153733-A1 | SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS | CCR2, CCR1, CCR5 | GRK2 80/4885CYP3A4 667/4885SLC6A4 3373/4885 |
| US-20190315691-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF PAROXETINE AND ITS INTERMEDIATE | CYP2D6, CYP2C19, CYP2B6 | GRK2 2052/4885CYP3A4 8/4885SLC6A4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.