Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19463451 | 1.00 | TBXAS1 (0.50) | TBXAS1KDM4EGRM8GRM4SMN1; SMN2 | |
| SCHEMBL20213798 | 0.90 | TBXAS1 (0.49) | TBXAS1KDM4EGRM8GRM4SMN1; SMN2 | |
| SCHEMBL8461393 | 0.86 | TBXAS1 (0.49) | TBXAS1GRM8GRM4SMN1; SMN2EPHX2 | |
| SCHEMBL30479399 | 0.84 | TBXAS1 (0.53) | TBXAS1GRM8GRM4SMN1; SMN2EPHX2 | |
| SCHEMBL28368180 | 0.84 | TBXAS1 (0.53) | TBXAS1GRM8GRM4SMN1; SMN2PPARG | |
| SCHEMBL25287082 | 0.83 | SMN1; SMN2 (0.50) | TBXAS1KDM4EGRM8GRM4SMN1; SMN2 | |
| SCHEMBL31038319 | 0.83 | SMN1; SMN2 (0.50) | TBXAS1KDM4EGRM8GRM4SMN1; SMN2 | |
| SCHEMBL744044 | 0.83 | TBXAS1 (0.48) | TBXAS1KDM4EGRM8GRM4SMN1; SMN2 | |
| SCHEMBL9768498 | 0.81 | TBXAS1 (0.54) | TBXAS1EPHX2PPARGPPARA | |
| SCHEMBL8500771 | 0.81 | GAA (0.44) | TBXAS1KDM4ESMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442583-A2 | COMPOSITIONS AND METHODS FOR TREATING PARANASAL MUCOSA DISEASES WITH NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS | Solis Herrera, Arturo (MX) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017178897-A2 | COMPOSITIONS AND METHODS FOR TREATING PARANASAL MUCOSA DISEASES WITH NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS | SOLIS HERRERA ARTURO (MX) | 2017-10-19 | — | — | WO | disclosed |