Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461393 | 0.91 | TBXAS1 (0.49) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL28368180 | 0.88 | TBXAS1 (0.53) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL235125 | 0.87 | SMN1; SMN2 (0.50) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL29852444 | 0.87 | SMN1; SMN2 (0.50) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL11004067 | 0.86 | SMN1; SMN2 (0.47) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL20213798 | 0.85 | TBXAS1 (0.49) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL19463451 | 0.83 | TBXAS1 (0.50) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL19463449 | 0.83 | TBXAS1 (0.50) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL25287082 | 0.81 | SMN1; SMN2 (0.50) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 | |
| SCHEMBL31038319 | 0.81 | SMN1; SMN2 (0.50) | TBXAS1SMN1; SMN2LMNAL3MBTL1GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |
| EP-0397044-A2 | Arylsulfonamides, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-11-14 | — | — | EP | disclosed |
| US-4632925-A | INSULIN LOWERING ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1986-12-30 | — | — | US | disclosed |
| US-4551460-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1985-11-05 | — | — | US | disclosed |