Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NT5E | P21589 | 1/20 | 0.59 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30987755 | 0.78 | KDM4E (0.44) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL18694299 | 0.76 | CFTR (0.63) | KDM4EHPGDALDH1A1CFTRPOLB | |
| SCHEMBL19465582 | 0.76 | CFTR (0.54) | KDM4EHPGDALDH1A1CFTR | |
| SCHEMBL24287500 | 0.76 | NT5E (0.58) | KDM4EHPGDALDH1A1NT5ERCE1 | |
| SCHEMBL18717626 | 0.75 | CFTR (0.61) | KDM4EHPGDALDH1A1RCE1CFTR | |
| Hydrochloric Acid SCHEMBL18693567 | 0.74 | CFTR (0.60) | KDM4EHPGDALDH1A1RCE1CFTR | |
| SCHEMBL18694568 | 0.74 | CFTR (0.64) | KDM4EHPGDALDH1A1CFTRPOLB | |
| SCHEMBL16499203 | 0.72 | L3MBTL1 (0.46) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL7418912 | 0.71 | SPR (0.72) | KDM4EHPGDALDH1A1RCE1SMN1; SMN2 | |
| SCHEMBL19465600 | 0.71 | CFTR (0.58) | KDM4EHPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |