Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GRK2 | P25098 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17998714 | 0.74 | ALDH1A1 (0.39) | ALDH1A1HIF1ATRPA1ROCK2ROCK1 | |
| SCHEMBL23808984 | 0.70 | ALOX15 (0.58) | ALDH1A1ALOX15TSHRMAPTSMN1; SMN2 | |
| SCHEMBL24754534 | 0.70 | IKBKE (0.43) | HCAR2HCAR3ALDH1A1ALOX15TSHR | |
| SCHEMBL11757495 | 0.70 | KDM6B (0.44) | HCAR2HCAR3ALDH1A1CDK2MAPK1 | |
| SCHEMBL19465565 | 0.70 | CSNK2A2 (0.41) | ALDH1A1GRK2CDK2CLK4SMN1; SMN2 | |
| SCHEMBL18321257 | 0.68 | GRK2 (0.53) | GRK2ROCK1SGK1CDK2CDK5 | |
| SCHEMBL18693315 | 0.67 | GRK2 (0.49) | GRK2CDK2MAPK1CLK2CLK4 | |
| SCHEMBL31721176 | 0.66 | KDM4E (0.46) | HCAR2ALDH1A1ALOX15TSHRHIF1A | |
| SCHEMBL31721178 | 0.66 | KDM4E (0.46) | HCAR2ALDH1A1ALOX15TSHRHIF1A | |
| SCHEMBL12944438 | 0.66 | IL1B (0.55) | HCAR2HCAR3ALDH1A1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |