Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 6/20 | 0.46 |
| ▸ | RXRB | P28702 | 6/20 | 0.46 |
| ▸ | RXRG | P48443 | 6/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972884 | 0.85 | CA2 (0.48) | ABCC4LMNAGAATSHRPTGS1 | |
| SCHEMBL68027 | 0.80 | LMNA (0.86) | ABCC4LMNAGAATSHRPTGS1 | |
| SCHEMBL18427891 | 0.80 | LMNA (0.86) | ABCC4LMNAGAATSHRPTGS1 | |
| SCHEMBL31370206 | 0.76 | SLC7A5 (0.54) | LMNAPTGS1PTGS2ALDH1A1HSD17B10 | |
| SCHEMBL31477842 | 0.76 | HRH3 (0.56) | CA2ALDH1A1 | |
| SCHEMBL1867386 | 0.76 | BCL2L1 (0.50) | TSHRCA2RXRARXRBRXRG | |
| SCHEMBL694974 | 0.74 | MAPT (0.48) | GAAALDH1A1HPGDHSD17B10 | |
| Felbinac SCHEMBL26084 | 0.74 | LMNA (1.00) | ABCC4LMNAGAATSHRPTGS1 | |
| SCHEMBL12126599 | 0.74 | LMNA (0.75) | ABCC4LMNAGAATSHRPTGS1 | |
| SCHEMBL69614 | 0.73 | CA2 (0.79) | ABCC4LMNAGAATSHRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9789100-B2 | Compounds as rearranged during transfection (RET) inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-10-17 | — | — | US | disclosed |