Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19466993 | 0.86 | IRAK4 (0.45) | NPSR1DPP4IRAK4TGFBR1DGAT1 | |
| SCHEMBL21765953 | 0.83 | IRAK4 (0.50) | NPSR1SMN1; SMN2IRAK4KDM4ELMNA | |
| SCHEMBL19467146 | 0.80 | DPP4 (0.63) | NPSR1DPP4SMN1; SMN2HPGDKDM4E | |
| SCHEMBL21637228 | 0.78 | NPC1 (0.58) | NPSR1DPP4SMN1; SMN2IRAK4KDM4E | |
| SCHEMBL19930451 | 0.73 | NPSR1 (0.61) | NPSR1DPP4SMN1; SMN2HPGDUSP30 | |
| SCHEMBL19657302 | 0.72 | TGFBR1 (0.47) | TGFBR1 | |
| SCHEMBL18126714 | 0.72 | DPP4 (0.64) | NPSR1DPP4SMN1; SMN2HPGDLMNA | |
| SCHEMBL8291757 | 0.71 | SMN1; SMN2 (0.70) | NPSR1DPP4SMN1; SMN2HPGDUSP30 | |
| SCHEMBL19930468 | 0.71 | CKS1B (0.51) | NPSR1DPP4SMN1; SMN2HPGDTSHR | |
| SCHEMBL19930437 | 0.71 | DPP4 (0.63) | NPSR1DPP4SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-2822555-B1 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | LEXICON PHARMACEUTICALS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3235499-A2 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | Lexicon Pharmaceuticals, Inc. (US) | 2017-10-25 | — | — | EP | disclosed |