Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814453 | 0.85 | ALDH1A1 (0.52) | POLBALDH1A1PKMTP53MEN1 | |
| SCHEMBL14583724 | 0.80 | TDP1 (0.49) | ALDH1A1TP53MAPTLMNACYP1A2 | |
| SCHEMBL14598299 | 0.77 | CALM1 (0.41) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL28504931 | 0.77 | TLR8 (0.69) | ALDH1A1MAPTNPSR1HTTLMNA | |
| SCHEMBL541447 | 0.77 | ALDH1A1 (0.42) | ALDH1A1TSHRMEN1KMT2AGAA | |
| SCHEMBL13703807 | 0.77 | AVPR1A (0.49) | ALDH1A1LMNATSHRSMN1; SMN2GAA | |
| SCHEMBL14112936 | 0.76 | TDP1 (0.49) | ALDH1A1TP53MAPTLMNACYP1A2 | |
| SCHEMBL6403944 | 0.75 | ALDH1A1 (0.60) | ALDH1A1TP53MAPTHTTTSHR | |
| SCHEMBL12768238 | 0.75 | GFER (0.60) | MAPTNPSR1SMN1; SMN2GAAVCP | |
| SCHEMBL17758387 | 0.73 | POLB (1.00) | POLBALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10864248-B2 | Dab2 inhibitors for the prevention and treatment of cystic fibrosis | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2020-12-15 | — | — | US | disclosed |
| US-20170304392-A1 | DAB2 INHIBITORS FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS | TRUSTEES OF DARTMOUTH COLLEGE | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10864248-B2 | Dab2 inhibitors for the prevention and treatment of cystic fibrosis | CFTR, DAB2IP, CLCN2 | POLB 3804/4885ALDH1A1 2913/4885PKM 4695/4885 |
| US-20170304392-A1 | DAB2 INHIBITORS FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS | CFTR, DAB2IP, CLCN2 | POLB 3811/4885ALDH1A1 2889/4885PKM 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.