Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 20/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18205749 | 0.88 | RORC (0.68) | RORCCYP2C9PPARGCYP3A4RARG | |
| SCHEMBL19471705 | 0.87 | RORC (1.00) | RORCCYP2C9PPARGCYP3A4RARG | |
| SCHEMBL19471816 | 0.85 | RORC (0.77) | RORCCYP2C9PPARGCYP3A4 | |
| SCHEMBL19471700 | 0.82 | RORC (1.00) | RORCCYP2C9PPARGCYP3A4 | |
| SCHEMBL21686880 | 0.81 | RORC (0.59) | RORCCYP2C9PPARGRARG | |
| SCHEMBL17978094 | 0.80 | RORC (0.69) | RORCPPARG | |
| SCHEMBL16797161 | 0.77 | RORC (0.70) | RORCCYP2C9CYP3A4RARG | |
| SCHEMBL18205745 | 0.77 | RORC (0.52) | RORCCYP2C9PPARGCYP3A4RARG | |
| SCHEMBL19471870 | 0.76 | RORC (1.00) | RORCCYP2C9CYP3A4RARG | |
| SCHEMBL16797176 | 0.75 | RORC (0.80) | RORCCYP2C9PPARGCYP3A4RARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170305915-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATES ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | ORCA PHARMACEUTICALS, LLC | 2017-10-26 | — | — | US | claimed |
| US-20200030290-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | ORCA PHARMACEUTICALS, LLC | 2020-01-30 | — | — | US | disclosed |
| US-10383850-B2 | Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases | ORCA PHARMACEUTICALS LIMITED (GB) | 2019-08-20 | — | — | US | disclosed |
| US-10383850-B2 | Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases | ORCA PHARMACEUTICALS LIMITED (GB) | 2019-08-20 | — | — | US | disclosed |
| US-20170305915-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATES ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | ORCA PHARMACEUTICALS, LLC | 2017-10-26 | — | — | US | disclosed |
| US-20170305915-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATES ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | ORCA PHARMACEUTICALS, LLC | 2017-10-26 | — | — | US | disclosed |
| US-20170305915-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATES ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | ORCA PHARMACEUTICALS, LLC | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10383850-B2 | Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases | RORA, RORB, RORC | RORC 3/4885CYP2C9 814/4885PPARG 71/4885 |
| US-20200030290-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | RORA, RORB, RORC | RORC 3/4885CYP2C9 814/4885PPARG 71/4885 |
| US-20170305915-A1 | INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATES ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES | RORA, RORB, RORC | RORC 3/4885CYP2C9 838/4885PPARG 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.