Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29961609 | 0.88 | NOTUM (0.46) | KDM4ENOTUMALDH1A1HSD17B10TSHR | |
| SCHEMBL23535750 | 0.84 | CHRM4 (0.47) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL31633138 | 0.81 | KDM4E (0.42) | KDM4ENOTUMALDH1A1HSD17B10TSHR | |
| SCHEMBL31633187 | 0.78 | PTGER4 (0.45) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL22789994 | 0.77 | L3MBTL1 (0.44) | TSHRMAPTHTTKMT2ARAB9A | |
| SCHEMBL7426182 | 0.77 | ALDH1A1 (0.43) | KDM4ENOTUMALDH1A1HSD17B10TSHR | |
| SCHEMBL29950049 | 0.77 | ALDH1A1 (0.43) | KDM4ENOTUMALDH1A1HSD17B10TSHR | |
| SCHEMBL11195889 | 0.74 | CA1 (0.53) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL30987624 | 0.73 | MAPT (0.44) | KDM4ENOTUMALDH1A1HSD17B10TSHR | |
| SCHEMBL20604896 | 0.73 | MAPT (0.44) | KDM4ENOTUMALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550080-B2 | Acyl sulfonamide NaV1.7 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190119209-A1 | ACYL SULFONAMIDE NaV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2017184658-A1 | ACYL SULFONAMIDE NaV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017184658-A1 | ACYL SULFONAMIDE NaV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550080-B2 | Acyl sulfonamide NaV1.7 inhibitors | SCN7A, SCN1A, SCN8A | KDM4E 1622/4885NOTUM 2164/4885ALDH1A1 1181/4885 |
| US-20190119209-A1 | ACYL SULFONAMIDE NaV1.7 INHIBITORS | SCN7A, SCN1A, SCN8A | KDM4E 1622/4885NOTUM 2164/4885ALDH1A1 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.