Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.49 |
| ▸ | CHRND | Q07001 | 5/20 | 0.48 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNG | P07510 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19477907 | 0.88 | CHRND (0.54) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL22175312 | 0.86 | CYP3A4 (0.68) | CYP3A4TSHRCTSL | |
| SCHEMBL19477908 | 0.85 | CHRND (0.61) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL22461945 | 0.84 | CHRND (0.47) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL15359366 | 0.84 | GRIA1 (0.46) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL7029376 | 0.82 | MMP1 (0.51) | CTSL | |
| SCHEMBL8022821 | 0.82 | MMP1 (0.51) | CTSL | |
| SCHEMBL16656679 | 0.82 | GRIA1 (0.46) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL16217709 | 0.82 | GRIA1 (0.46) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL21415384 | 0.82 | GRIA1 (0.46) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081420-A2 | CONJUGATES AND METHODS FOR TREATING ACROMEGALY | GENEVANT SCIENCES GMBH (CH) | 2021-04-29 | — | — | WO | disclosed |
| WO-2020191207-A1 | THERAPEUTIC METHODS FOR TREATING HEPATITIS B | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-09-24 | — | — | WO | disclosed |
| WO-2019051257-A2 | METHODS FOR TREATING HEPATITIS B INFECTIONS | ARBUTUS BIOPHARMA CORPORATION (CA) | 2019-03-14 | — | — | WO | disclosed |
| WO-2017177326-A1 | TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS | PROTIVA BIOTHERAPEUTICS, INC. (CA) | 2017-10-19 | — | — | WO | disclosed |