Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | MAP2 | P11137 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571189 | 0.88 | KDM4E (0.43) | MAP2KDM4EFFAR1JAK2MAPT | |
| SCHEMBL16571203 | 0.86 | GRM2 (0.41) | GRM2MAP2HRH4JAK2 | |
| SCHEMBL16571716 | 0.83 | MAP2 (0.43) | GRM2MAP2KDM4EPPARGSMN1; SMN2 | |
| SCHEMBL19478200 | 0.81 | CCNC (0.48) | — | |
| SCHEMBL19478158 | 0.79 | GRM2 (0.45) | GRM2 | |
| SCHEMBL16571044 | 0.79 | MPL (0.39) | GRM2MAPT | |
| SCHEMBL16571180 | 0.77 | SLC22A12 (0.42) | GRM2MAP2KDM4E | |
| SCHEMBL16571281 | 0.77 | BRD4 (0.37) | GRM2 | |
| SCHEMBL16571158 | 0.76 | ALOX15 (0.49) | KDM4EMEN1LMNAGAAHPGD | |
| SCHEMBL16580061 | 0.75 | PARP1 (0.39) | GRM2MAP2JAK2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |