Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 3/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555705 | 0.82 | HTR7 (0.59) | HTR7CAMK2DMAPK14ADRA1DHTR2C | |
| SCHEMBL17439303 | 0.82 | HTR7 (0.56) | HTR7CAMK2DMAPK14ADRA1DHTR2C | |
| SCHEMBL7232240 | 0.80 | AR (0.55) | HTR7CAMK2DMAPK14ADRA1DHTR2C | |
| SCHEMBL10594962 | 0.79 | KDM4E (0.56) | HTR7FDPS | |
| SCHEMBL17560828 | 0.79 | HTR7 (0.70) | HTR7PLK1 | |
| SCHEMBL5981398 | 0.79 | KDM4E (0.56) | HTR7FDPS | |
| SCHEMBL7242746 | 0.78 | HTR7 (0.52) | HTR7CAMK2DMAPK14ADRA1DHTR2C | |
| SCHEMBL29851369 | 0.78 | FDPS (0.59) | MAPK14NOS2FDPS | |
| SCHEMBL828257 | 0.78 | FDPS (0.59) | MAPK14NOS2FDPS | |
| SCHEMBL828253 | 0.77 | FDPS (0.57) | MAPK14NOS2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970323-B1 | FUROPYRIDINES AS BROMODOMAIN INHIBITORS. | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD (GB) | 2017-10-18 | — | — | EP | disclosed |