SCHEMBL19478474

SCHEMBL19478474

Cc1ccncc1OCC1CCO1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.57
CHRNA4 P43681 1/20 0.57
ALDH1A1 P00352 1/20 0.45
GLA P06280 1/20 0.45
SSTR4 P31391 1/20 0.42
CHRNB4 P30926 2/20 0.41
CHRNA3 P32297 2/20 0.41
CNR2 P34972 1/20 0.39
PKM P14618 1/20 0.38
GRM5 P41594 2/20 0.37
ADRB2 P07550 1/20 0.37
HTR1A P08908 1/20 0.37
SLC6A2 P23975 1/20 0.37
HTR2A P28223 1/20 0.37
SLC6A4 P31645 1/20 0.37
ADRA1A P35348 1/20 0.37
HTR2B P41595 1/20 0.37
SLC6A3 Q01959 1/20 0.37
ADRA2C P18825 1/20 0.37
DRD4 P21917 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19478450 1.00 CHRNB2 (0.57) CHRNB2CHRNA4ALDH1A1GLASSTR4
Ammonia Solution, Strong SCHEMBL28932670 0.84 CHRNB2 (0.51) CHRNB2CHRNA4ALDH1A1GLASSTR4
SCHEMBL16052392 0.83 CHRNB2 (0.40) CHRNB2CHRNA4ALDH1A1GLACHRNB4
SCHEMBL16052980 0.83 CHRNB2 (0.40) CHRNB2CHRNA4ALDH1A1GLACHRNB4
SCHEMBL18133748 0.82 CHRNB2 (0.61) CHRNB2CHRNA4SSTR4CHRNB4CHRNA3
Ammonia Solution, Strong SCHEMBL28406800 0.81 CHRNB2 (0.59) CHRNB2CHRNA4SSTR4CHRNB4CHRNA3
SCHEMBL23888514 0.81 AOC1 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3CNR2
SCHEMBL22588480 0.81 GPR84 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3CNR2
SCHEMBL22588547 0.81 GPR84 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3CNR2
SCHEMBL22588514 0.81 AOC1 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970323-B1 FUROPYRIDINES AS BROMODOMAIN INHIBITORS. GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD (GB) 2017-10-18 EP disclosed