Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15885475 | 0.80 | CASP6 (0.47) | KEAP1KMT2ACASP6MKNK1MKNK2 | |
| SCHEMBL22940968 | 0.79 | CASP6 (0.49) | KEAP1KMT2ACASP6ADORA2AADRA1D | |
| SCHEMBL1850624 | 0.79 | KMT2A (0.44) | KEAP1KMT2ACASP6ADRA1DADRA1A | |
| SCHEMBL22940967 | 0.76 | RAB9A (0.47) | KMT2ACASP6JMJD6JAK2JAK3 | |
| SCHEMBL22230356 | 0.76 | KEAP1 (0.50) | KEAP1KMT2AADORA2ATGFBR1JMJD6 | |
| SCHEMBL11377293 | 0.76 | KMT2A (0.53) | KEAP1KMT2AADRA1DADRA1AADRA1B | |
| SCHEMBL30211937 | 0.75 | KEAP1 (0.46) | KEAP1KMT2ACASP6ADORA2ATGFBR1 | |
| SCHEMBL4240350 | 0.74 | MAP4K4 (0.40) | NOS3NOS1NOS2MAP4K4MKNK1 | |
| SCHEMBL10062975 | 0.73 | MAP4K4 (0.59) | KMT2ANOS3NOS1NOS2MAP4K4 | |
| SCHEMBL17812984 | 0.72 | KMT2A (0.54) | KEAP1KMT2ACASP6NTRK1JMJD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126844-A1 | AMIDE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021197276-A1 | Amide compounds and uses thereof | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-10-07 | — | — | WO | disclosed |
| WO-2017178344-A1 | NOVEL N-[(HETEROARYLOXY)PROPANYL]HETEROARYL CARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |