SCHEMBL19484151

SCHEMBL19484151

COCc1onc(C(=O)NC(C)C(C)C)c1C(C)F

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 4/20 0.40
TAS1R3 Q7RTX0 2/20 0.33
TAS1R1 Q7RTX1 2/20 0.33
TAS1R2 Q8TE23 2/20 0.33
LMNA P02545 2/20 0.32
CYP1A2 P05177 1/20 0.32
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
HPGD P15428 1/20 0.31
ATM Q13315 1/20 0.31
NPC1 O15118 1/20 0.30
TP53 P04637 1/20 0.30
HTT P42858 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19484138 0.88 TRPV1 (0.38) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL17483110 0.85 TRPV1 (0.47) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL19483600 0.85 TRPV1 (0.42) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL19488032 0.84 TRPV1 (0.41) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL19484146 0.83 TRPV1 (0.40) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL19484137 0.82 TRPV1 (0.45) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL19484145 0.82 KMT2A (0.45) TAS1R3TAS1R1TAS1R2LMNAALDH1A1
SCHEMBL19484147 0.81 TRPV1 (0.51) TRPV1TAS1R3TAS1R1TAS1R2LMNA
SCHEMBL19484142 0.80 MEN1 (0.36) TRPV1LMNAALDH1A1HPGDNPC1
SCHEMBL19484143 0.78 NPC1 (0.32) TRPV1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170295789-A1 AMIDE COMPOUND AND USE OF SAME FOR NOXIOUS ARTHROPOD CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170295789-A1 AMIDE COMPOUND AND USE OF SAME FOR NOXIOUS ARTHROPOD CONTROL OPRM1, TRPA1, L3MBTL3 TRPV1 52/4885TAS1R3 1080/4885TAS1R1 1146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.