Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19485771 | 0.92 | HTR2A (0.42) | HTR2AHTR2CHTR2BSIGMAR1ABL1 | |
| SCHEMBL22536330 | 0.92 | HTR2A (0.42) | HTR2AHTR2CHTR2BSIGMAR1ABL1 | |
| SCHEMBL11405537 | 0.82 | HTR2A (0.63) | HTR2AHTR2CHTR2BSIGMAR1CYP1A2 | |
| SCHEMBL24806246 | 0.80 | GABRA1 (0.47) | HTR2AHTR2BCYP1A2GABRA1GABRB2 | |
| SCHEMBL20008485 | 0.80 | GABRA1 (0.47) | HTR2AHTR2BCYP1A2GABRA1GABRB2 | |
| SCHEMBL3677922 | 0.80 | HTR2A (0.71) | HTR2AHTR2CHTR2BSIGMAR1CYP1A2 | |
| SCHEMBL28292686 | 0.80 | HTR2A (0.57) | HTR2AHTR2CHTR2BSIGMAR1ABL1 | |
| SCHEMBL30127774 | 0.71 | NOX1 (0.58) | HTR2CCYP1A2CYP2A6BCHENPC1 | |
| SCHEMBL10706836 | 0.71 | NOX1 (0.58) | HTR2CCYP1A2CYP2A6BCHENPC1 | |
| SCHEMBL24819489 | 0.71 | HTR2A (0.48) | HTR2AHTR2CHTR2BSIGMAR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796754-B2 | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives | AMBRX, INC. (US) | 2017-10-24 | — | — | US | disclosed |