Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | VDR | P11473 | 3/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13997365 | 0.89 | MRGPRX4 (0.50) | SSTR4MRGPRX4KDM4EPPARDMCHR1 | |
| SCHEMBL13602336 | 0.86 | SSTR4 (0.48) | SSTR4MRGPRX4KDM4EPPARDMCHR1 | |
| SCHEMBL17815980 | 0.84 | CYP2C9 (0.45) | MRGPRX4KDM4EVDRLMNAMAPT | |
| SCHEMBL24314196 | 0.82 | KDM4E (0.57) | SSTR4MRGPRX4KDM4EPPARDMCHR1 | |
| SCHEMBL12674477 | 0.81 | CYP1A2 (0.56) | SSTR4MRGPRX4KDM4EPPARDVDR | |
| SCHEMBL14471138 | 0.79 | PPARG (0.51) | MRGPRX4KDM4EPPARDL3MBTL1 | |
| SCHEMBL15669956 | 0.78 | VDR (0.40) | SSTR4MRGPRX4MCHR1VDRFFAR4 | |
| SCHEMBL17811815 | 0.78 | ACHE (0.41) | KDM4EVDRLMNAL3MBTL1 | |
| SCHEMBL14453572 | 0.77 | KDM4E (0.58) | MRGPRX4KDM4EPPARDFFAR4FFAR1 | |
| SCHEMBL165552 | 0.77 | ESR1 (0.57) | SSTR4MRGPRX4KDM4EPPARDFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3231798-A1 | THIAZOLE INTERMEDIATES USEFUL IN THE PREPARATION OF RAF KINASE INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2017-10-18 | — | — | EP | disclosed |