Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | VDR | P11473 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13997365 | 0.89 | MRGPRX4 (0.50) | KDM4EALDH1A1MRGPRX4SSTR4KMT2A | |
| SCHEMBL20347963 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL4859856 | 0.84 | KDM4E (0.42) | KDM4ERECQLALDH1A1SSTR4KMT2A | |
| SCHEMBL29469845 | 0.83 | KDM4E (0.41) | KDM4ERECQLALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL24314198 | 0.83 | KDM4E (0.41) | KDM4ERECQLALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL19489148 | 0.82 | SSTR4 (0.50) | KDM4EMRGPRX4SSTR4MAPTL3MBTL1 | |
| SCHEMBL12017707 | 0.81 | L3MBTL1 (0.46) | KDM4EALDH1A1SMN1; SMN2MRGPRX4KMT2A | |
| SCHEMBL20347950 | 0.81 | KDM4E (0.42) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL2031055 | 0.80 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14409249 | 0.80 | SSTR4 (0.46) | KDM4EALDH1A1SMN1; SMN2MRGPRX4SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |