Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29705827 | 0.99 | HTR2C (0.36) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| Hydrochloric Acid SCHEMBL19464268 | 0.99 | HTR2C (0.36) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| SCHEMBL19489539 | 0.81 | MAOA (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| SCHEMBL19489410 | 0.81 | MAOA (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| SCHEMBL19489661 | 0.81 | MAOA (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| SCHEMBL22870615 | 0.81 | MAOA (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| Hydrochloric Acid SCHEMBL29607187 | 0.80 | HTR2C (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| Hydrochloric Acid SCHEMBL29607281 | 0.80 | HTR2C (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| Hydrochloric Acid SCHEMBL29607008 | 0.80 | HTR2C (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 | |
| Hydrochloric Acid SCHEMBL28825237 | 0.80 | HTR2C (0.34) | HTR2CHTR2AMAOADRD2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442945-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SRL (BE) | 2020-07-08 | — | — | EP | disclosed |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | disclosed |
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2019-04-11 | — | — | US | disclosed |
| WO-2017178377-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | GPR52, GRK3, GPR3 | HTR2C 48/4885HTR2A 58/4885MAOA 1713/4885 |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | GPR52, GRK3, GPR3 | HTR2C 48/4885HTR2A 58/4885MAOA 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.