Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | NR1D1 | P20393 | 4/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22038599 | 1.00 | AKT1 (0.45) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL17986810 | 1.00 | AKT1 (0.45) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL17986809 | 0.88 | AKT1 (0.46) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL782348 | 0.87 | AKT1 (0.55) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL13163615 | 0.84 | TSHR (0.53) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL782349 | 0.83 | AKT1 (0.51) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL23130693 | 0.82 | AKT1 (0.50) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL30915258 | 0.82 | AKT1 (0.50) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL7570965 | 0.82 | AKT1 (0.50) | AKT1NR1D1NR1H3CTSLCTSB | |
| SCHEMBL8018235 | 0.82 | AKT1 (0.50) | AKT1NR1D1NR1H3CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150367-A1 | NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2024-05-09 | — | — | US | disclosed |
| CN-117865992-A | Process for preparing 7H-pyrrolo [2,3-d ] pyrimidine derivatives and synthetic intermediates therefor | 日本烟草产业株式会社 | 2024-04-12 | — | — | CN | disclosed |
| CN-110300756-B | Process for preparing 7H-pyrrolo [2,3-d ] pyrimidine derivatives and synthetic intermediates therefor | 日本烟草产业株式会社 | 2024-01-02 | — | — | CN | disclosed |
| US-20230023377-A1 | NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2023-01-26 | — | — | US | disclosed |
| US-20230023377-A1 | NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2023-01-26 | — | — | US | disclosed |
| CN-110099910-B | Preparation method of 7H-pyrrolo [2,3-d ] pyrimidine derivative and eutectic crystal thereof | 日本烟草产业株式会社 | 2022-12-20 | — | — | CN | disclosed |
| CN-107709337-B | Process for the preparation of 7H-pyrrolo [2, 3-d ] pyrimidine derivatives and intermediates therefor | 日本烟草产业株式会社 | 2021-11-16 | — | — | CN | disclosed |
| EP-3858349-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco Inc. (JP) | 2021-08-04 | — | — | EP | disclosed |
| EP-3858349-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco Inc. (JP) | 2021-08-04 | — | — | EP | disclosed |
| CN-110300756-A | Preparation method of 7H-pyrrolo [2,3-d ] pyrimidine derivative and synthetic intermediate thereof | 日本烟草产业株式会社 | 2019-10-01 | — | — | CN | disclosed |
| US-20140187534-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2014-07-03 | — | — | US | disclosed |
| US-20140187534-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2014-07-03 | — | — | US | disclosed |
| US-20140187534-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2014-07-03 | — | — | US | disclosed |
| US-8609647-B2 | Nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof | JAPAN TOBACCO INC. (JP) | 2013-12-17 | — | — | US | disclosed |
| EP-2460806-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco, Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |
| EP-2460806-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco, Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20110136778-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2011-06-09 | — | — | US | disclosed |
| US-20110136778-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2011-06-09 | — | — | US | disclosed |
| US-20110136778-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2011-06-09 | — | — | US | disclosed |
| WO-2011013785-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | 日本たばこ産業株式会社 (JP) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136778-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | REN, PKD1, NR3C2 | AKT1 638/4885NR1D1 88/4885NR1H3 427/4885 |
| US-20230023377-A1 | NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | REN, PKD1, NPR1 | AKT1 478/4885NR1D1 176/4885NR1H3 924/4885 |
| US-20140187534-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | REN, PKD1, NR3C2 | AKT1 638/4885NR1D1 88/4885NR1H3 427/4885 |
| US-20240150367-A1 | NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF | REN, PKD1, NPR1 | AKT1 458/4885NR1D1 146/4885NR1H3 929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.