Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CFTR | P13569 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494889 | 0.87 | NPC1 (0.48) | RAB9ANPC1MAPTLMNAL3MBTL1 | |
| SCHEMBL19494688 | 0.85 | MAPT (0.52) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL19494409 | 0.79 | IRAK4 (0.48) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL19494581 | 0.79 | CFTR (0.47) | RAB9ACFTRNPC1MAPTMAPK1 | |
| SCHEMBL16338424 | 0.79 | CFTR (0.64) | RAB9ACFTRNPC1MAPTLMNA | |
| SCHEMBL19494403 | 0.78 | RAB9A (0.52) | RAB9ACFTRNPC1MAPTLMNA | |
| SCHEMBL19494498 | 0.78 | CFTR (0.40) | RAB9ACFTRMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL16261720 | 0.77 | RAB9A (0.47) | RAB9ACFTRNPC1MAPTLMNA | |
| SCHEMBL19494684 | 0.77 | NPC1 (0.46) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL19494323 | 0.77 | CHEK1 (0.37) | RAB9ACFTRNPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |