Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | BRD1 | O95696 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TAF1 | P21675 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494270 | 0.85 | RAB9A (0.48) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494889 | 0.85 | NPC1 (0.48) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL16246327 | 0.79 | CFTR (0.60) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494581 | 0.78 | CFTR (0.47) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494409 | 0.77 | IRAK4 (0.48) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494346 | 0.77 | RAB9A (0.41) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494323 | 0.77 | CHEK1 (0.37) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494403 | 0.76 | RAB9A (0.52) | MAPTKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL19494498 | 0.76 | CFTR (0.40) | MAPTKDM4EKMT2ARAB9AGFER | |
| SCHEMBL19494684 | 0.75 | NPC1 (0.46) | MAPTKDM4EKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |