Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494684 | 0.90 | NPC1 (0.46) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494270 | 0.87 | RAB9A (0.48) | NPC1RAB9AKDM4EALDH1A1NPSR1 | |
| SCHEMBL19494717 | 0.87 | NPC1 (0.46) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494637 | 0.86 | NPC1 (0.45) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494434 | 0.86 | NPC1 (0.45) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494346 | 0.85 | RAB9A (0.41) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494688 | 0.85 | MAPT (0.52) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494729 | 0.83 | NPC1 (0.42) | NPC1RAB9AKDM4EHTTALDH1A1 | |
| SCHEMBL19494506 | 0.81 | NPC1 (0.49) | NPC1RAB9AKDM4EALDH1A1GLA | |
| SCHEMBL19494409 | 0.79 | IRAK4 (0.48) | NPC1RAB9AKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |