Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 13/20 | 0.71 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17881881 | 0.86 | RIPK1 (0.71) | RIPK1FKBP1AMEN1TSHRHTT | |
| SCHEMBL17881878 | 0.86 | RIPK1 (0.71) | RIPK1FKBP1AMEN1TSHRHTT | |
| SCHEMBL17881984 | 0.83 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL17881976 | 0.83 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19512619 | 0.79 | RIPK1 (0.60) | RIPK1FKBP1A | |
| SCHEMBL14068810 | 0.78 | GPR119 (0.48) | RIPK1PRMT5WDR77 | |
| SCHEMBL17881895 | 0.78 | RIPK1 (0.84) | RIPK1FKBP1A | |
| SCHEMBL17881874 | 0.78 | RIPK1 (0.65) | RIPK1 | |
| SCHEMBL17881908 | 0.78 | RIPK1 (0.65) | RIPK1 | |
| SCHEMBL17881868 | 0.78 | RIPK1 (0.65) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170304237-A1 | Necrosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304237-A1 | Necrosis Inhibitors | RIPK3, RIPK1, RIPK4 | RIPK1 2/4885PRMT5 2806/4885WDR77 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.