Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 12/20 | 0.38 |
| ▸ | CES1 | P23141 | 11/20 | 0.37 |
| ▸ | CES2 | O00748 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19501033 | 1.00 | FAAH (0.38) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL1492542 | 0.79 | ALDH1A1 (0.46) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL27044758 | 0.77 | FAAH (0.39) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL19501024 | 0.76 | FAAH (0.45) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL14770953 | 0.76 | FAAH (0.45) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL13864005 | 0.75 | FAAH (0.38) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL20995341 | 0.75 | FAAH (0.38) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL30358256 | 0.75 | FAAH (0.38) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL26302474 | 0.75 | FAAH (0.38) | FAAHCES1CES2MEN1CYP1A2 | |
| SCHEMBL8793317 | 0.75 | FAAH (0.38) | FAAHCES1CES2MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218638-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| US-20230192756-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | Sage Therapeutics, LLC | 2023-06-22 | — | — | US | disclosed |
| US-10759828-B2 | Neuroactive steroids, compositions, and uses thereof | SAGE THERAPEUTICS, INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS INC (US) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759828-B2 | Neuroactive steroids, compositions, and uses thereof | CHRNB4, CHRNB3, MC2R | FAAH 1396/4885CES1 1084/4885CES2 762/4885 |
| US-20230192756-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CHRNB4, CHRNB3, MC2R | FAAH 1516/4885CES1 1147/4885CES2 764/4885 |
| US-20230218638-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | GRIN3B, GRIN2A, GRIN1 | FAAH 854/4885CES1 915/4885CES2 348/4885 |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | GRIN3B, GRIN2A, GRIN1 | FAAH 854/4885CES1 915/4885CES2 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.