Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.39 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248552 | 0.97 | ESR1 (0.42) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL19502201 | 0.96 | RECQL (0.45) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL22912413 | 0.95 | ESR1 (0.42) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL18314345 | 0.94 | PTGER4 (0.44) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL19502207 | 0.92 | RECQL (0.47) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL18314571 | 0.92 | ALOX5 (0.42) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL19502177 | 0.92 | ESR1 (0.41) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL22912414 | 0.92 | ESR1 (0.43) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL19502138 | 0.91 | ESR1 (0.41) | ESR1ESR2HDAC1HDAC8HDAC6 | |
| SCHEMBL22177437 | 0.91 | ESR1 (0.41) | ESR1ESR2HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190165282-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-05-30 | — | — | US | disclosed |
| WO-2017178311-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190165282-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | DDT, NUDT1, ETFB | ESR1 1158/4885ESR2 1289/4885HDAC1 4461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.