Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 15/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25068274 | 0.92 | PKM (0.47) | PKMPDK1PDK2PDK3PDK4 | |
| SCHEMBL3811514 | 0.86 | ALDH1A1 (0.51) | SMYD3PKMPDK1PDK2PDK3 | |
| SCHEMBL14654898 | 0.84 | EPHX1 (0.50) | PKMPDK1PDK2PDK3PDK4 | |
| SCHEMBL9498299 | 0.84 | EPHX2 (0.54) | PKMPDK1PDK2PDK3PDK4 | |
| SCHEMBL14654944 | 0.84 | EPHX1 (0.50) | PKMPDK1PDK2PDK3PDK4 | |
| SCHEMBL14243258 | 0.82 | PDK1 (0.59) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL14652052 | 0.79 | PKM (0.42) | SMYD3PKMPDK1PDK2PDK3 | |
| SCHEMBL14652022 | 0.79 | PKM (0.42) | SMYD3PKMPDK1PDK2PDK3 | |
| SCHEMBL9795122 | 0.79 | PKM (0.38) | PKMPDK1PDK2PDK3PDK4 | |
| Oxalic Acid SCHEMBL9795398 | 0.79 | EPHX2 (0.48) | PKMPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464273-B9 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-10-21 | — | — | EP | disclosed |
| EP-3464273-B1 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-04-08 | — | — | EP | disclosed |
| EP-3464268-B1 | NOVEL COMPOUNDS | CHIESI FARM SPA (IT) | 2020-03-11 | — | — | EP | disclosed |
| US-9802919-B1 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-10-31 | — | — | US | disclosed |