Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.57 |
| ▸ | PNP | P00491 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | CHKA | P35790 | 8/20 | 0.51 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503306 | 1.00 | PDE4D (0.57) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL19575553 | 0.93 | PDE4D (0.57) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL27087643 | 0.89 | LMNA (0.53) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL10475246 | 0.88 | AHCY (0.58) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL9208531 | 0.84 | ADCY5 (0.49) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL9208537 | 0.84 | ADCY5 (0.49) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL9767445 | 0.84 | ADCY5 (0.49) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL7656365 | 0.84 | ADORA3 (0.60) | PDE4DPDE3APNPLMNATP53 | |
| Hydrochloric Acid SCHEMBL7665371 | 0.82 | ADORA3 (0.59) | PDE4DPDE3APNPLMNATP53 | |
| SCHEMBL19503356 | 0.82 | ADCY5 (0.48) | ADORA3ADORA2AADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017185061-A1 | COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS | ASTROCYTE PHARMACEUTICALS, INC. (US) | 2017-10-26 | — | — | WO | disclosed |