Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WIZ | O95785 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 13/20 | 0.44 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503564 | 0.88 | POLB (0.43) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL17552859 | 0.80 | CRBN (0.69) | WIZCRBNIKZF2CSNK1A1 | |
| SCHEMBL24319331 | 0.80 | CRBN (0.69) | WIZCRBNIKZF2CSNK1A1 | |
| SCHEMBL24891513 | 0.77 | IKZF2 (0.45) | CRBNIKZF2 | |
| SCHEMBL27117194 | 0.77 | WIZ (0.40) | WIZCRBNIKZF2 | |
| SCHEMBL25993290 | 0.76 | CRBN (0.55) | WIZCRBNIKZF2 | |
| SCHEMBL26000355 | 0.76 | CRBN (0.54) | WIZCRBNIKZF2 | |
| SCHEMBL19503553 | 0.74 | CRBN (0.47) | CRBNDDB1 | |
| SCHEMBL26022267 | 0.74 | IKZF2 (0.52) | WIZCRBNIKZF2 | |
| SCHEMBL25994256 | 0.74 | HRH3 (0.36) | WIZCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |
| WO-2017184995-A1 | COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF | BIOVENTURES, LLC (US) | 2017-10-26 | — | — | WO | disclosed |