Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 13/20 | 0.42 |
| ▸ | IKZF2 | Q9UKS7 | 7/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503552 | 0.88 | WIZ (0.45) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL19503782 | 0.86 | CRBN (0.55) | POLBIKZF1CRBNIKZF2 | |
| SCHEMBL19503638 | 0.81 | CRBN (0.65) | IKZF1CRBNIKZF2CSNK1A1 | |
| SCHEMBL19503563 | 0.76 | CRBN (0.45) | IKZF1CRBN | |
| SCHEMBL19503639 | 0.75 | CRBN (0.69) | IKZF1CRBNIKZF2CSNK1A1 | |
| SCHEMBL24891513 | 0.75 | IKZF2 (0.45) | IKZF1CRBNIKZF2 | |
| SCHEMBL27117194 | 0.74 | WIZ (0.40) | CRBNIKZF2 | |
| SCHEMBL25993290 | 0.74 | CRBN (0.55) | CRBNIKZF2 | |
| SCHEMBL19503783 | 0.73 | CRBN (0.51) | IKZF1CRBNIKZF2CSNK1A1 | |
| SCHEMBL26000355 | 0.73 | CRBN (0.54) | CRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184995-A1 | COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF | BIOVENTURES, LLC (US) | 2017-10-26 | — | — | WO | disclosed |