Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 11/20 | 0.45 |
| ▸ | TNF | P01375 | 7/20 | 0.42 |
| ▸ | IL1B | P01584 | 4/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24042667 | 0.93 | CRBN (0.53) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19503553 | 0.88 | CRBN (0.47) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL21303950 | 0.81 | CRBN (0.66) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL21303948 | 0.81 | CRBN (0.66) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19503643 | 0.81 | CRBN (0.66) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19504240 | 0.80 | CRBN (0.53) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19503783 | 0.80 | CRBN (0.51) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19504239 | 0.79 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL25893375 | 0.77 | CRBN (0.53) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19503564 | 0.76 | POLB (0.43) | CRBNIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184995-A1 | COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF | BIOVENTURES, LLC (US) | 2017-10-26 | — | — | WO | disclosed |