SCHEMBL1950595

SCHEMBL1950595

COc1ccc(C(=O)C(F)(F)F)c(OC)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.58
MAPT P10636 4/20 0.53
ALDH1A1 P00352 1/20 0.53
HPGD P15428 1/20 0.53
RAD52 P43351 1/20 0.53
ABCG2 Q9UNQ0 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.52
RAB9A P51151 2/20 0.52
KMT2A Q03164 4/20 0.51
TNFRSF1A P19438 1/20 0.51
MEN1 O00255 3/20 0.50
LMNA P02545 2/20 0.50
PDE4A P27815 1/20 0.50
PDE4B Q07343 1/20 0.50
PDE4C Q08493 1/20 0.50
PDE4D Q08499 1/20 0.50
TP53 P04637 1/20 0.50
HTT P42858 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27914477 0.87 NPC1 (0.55) NPC1MAPTALDH1A1HPGDRAD52
SCHEMBL855232 0.84 NPC1 (0.60) NPC1MAPTALDH1A1HPGDRAD52
SCHEMBL32665938 0.83 HTT (0.54) NPC1MAPTALDH1A1HPGDRAB9A
SCHEMBL20309092 0.83 ACHE (0.47) NPC1MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL4125439 0.81 SMN1; SMN2 (0.53) NPC1ALDH1A1SMN1; SMN2RAB9ATSHR
SCHEMBL27944733 0.81 ALDH1A1 (0.50) NPC1MAPTALDH1A1HPGDRAD52
SCHEMBL31575666 0.80 NPC1 (0.79) NPC1MAPTALDH1A1HPGDRAD52
SCHEMBL285924 0.80 NPC1 (0.79) NPC1MAPTALDH1A1HPGDRAD52
SCHEMBL11947787 0.79 CYP4F2 (0.45) NPC1ALDH1A1SMN1; SMN2RAB9AKMT2A
SCHEMBL226546 0.79 NPC1 (0.58) NPC1MAPTALDH1A1HPGDRAD52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9201318-B2 Polymer for charge generation layer and charge transport layer formulation XEROX CORPORATION (US) 2015-12-01 US claimed
US-20150024310-A1 POLYMER FOR CHARGE GENERATION LAYER AND CHARGE TRANSPORT LAYER FORMULATION XEROX CORPORATION 2015-01-22 US claimed
US-8877413-B2 Flexible imaging members comprising improved ground strip XEROX CORPORATION (US) 2014-11-04 US claimed
US-8614038-B2 Plasticized anti-curl back coating for flexible imaging member XEROX CORPORATION (US) 2013-12-24 US claimed
US-20130216266-A1 IMAGING MEMBERS COMPRISING FLUOROKETONE XEROX CORPORATION (US) 2013-08-22 US claimed
US-20130202995-A1 PLASTICIZED ANTI-CURL BACK COATING FOR FLEXIBLE IMAGING MEMBER XEROX CORPORATION (US) 2013-08-08 US claimed
US-20130052576-A1 FLEXIBLE IMAGING MEMBERS COMPRISING IMPROVED GROUND STRIP XEROX CORPORATION (US) 2013-02-28 US claimed
US-8343700-B2 Imaging members having stress/strain free layers XEROX CORPORATION (US) 2013-01-01 US claimed
US-8232030-B2 Curl-free imaging members with a slippery surface XEROX CORPORATION (US) 2012-07-31 US claimed
US-20110256474-A1 IMAGING MEMBERS HAVING STRESS/STRAIN FREE LAYERS XEROX CORPORATION (US) 2011-10-20 US claimed
US-20110229808-A1 CURL-FREE IMAGING MEMBERS WITH A SLIPPERY SURFACE XEROX CORPORATION (US) 2011-09-22 US claimed
US-20110136049-A1 IMAGING MEMBERS COMPRISING FLUOROKETONE XEROX CORPORATION (US) 2011-06-09 US claimed
US-9201318-B2 Polymer for charge generation layer and charge transport layer formulation XEROX CORPORATION (US) 2015-12-01 US disclosed
US-9201318-B2 Polymer for charge generation layer and charge transport layer formulation XEROX CORPORATION (US) 2015-12-01 US disclosed
US-20150024310-A1 POLYMER FOR CHARGE GENERATION LAYER AND CHARGE TRANSPORT LAYER FORMULATION XEROX CORPORATION 2015-01-22 US disclosed
US-20150024310-A1 POLYMER FOR CHARGE GENERATION LAYER AND CHARGE TRANSPORT LAYER FORMULATION XEROX CORPORATION 2015-01-22 US disclosed
US-20110229808-A1 CURL-FREE IMAGING MEMBERS WITH A SLIPPERY SURFACE XEROX CORPORATION (US) 2011-09-22 US disclosed
US-20110229808-A1 CURL-FREE IMAGING MEMBERS WITH A SLIPPERY SURFACE XEROX CORPORATION (US) 2011-09-22 US disclosed
US-20110136049-A1 IMAGING MEMBERS COMPRISING FLUOROKETONE XEROX CORPORATION (US) 2011-06-09 US disclosed
US-20110136049-A1 IMAGING MEMBERS COMPRISING FLUOROKETONE XEROX CORPORATION (US) 2011-06-09 US disclosed