SCHEMBL19506902

SCHEMBL19506902

C=COC(=O)c1ccc(-c2ccc(C(=O)OC=C)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41
CA12 O43570 3/20 0.39
CA1 P00915 3/20 0.39
CA2 P00918 3/20 0.39
CA9 Q16790 3/20 0.39
CA14 Q9ULX7 3/20 0.39
KDM4E B2RXH2 2/20 0.39
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ERN1 O75460 1/20 0.39
SENP1 Q9P0U3 1/20 0.37
ALDH1A1 P00352 1/20 0.36
SLC1A5 Q15758 1/20 0.36
PTPN1 P18031 1/20 0.36
BCL2L1 Q07817 1/20 0.35
BAD Q92934 1/20 0.35
HSD17B1 P14061 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL295796 0.93 ALDH1A1 (0.40) CA12CA1CA2CA9CA14
SCHEMBL760985 0.92 PDCD1 (0.53) PDCD1CD274KDM4ELMNASMN1; SMN2
SCHEMBL28944014 0.91 ALDH1A1 (0.39) CA12CA1CA2CA9CA14
SCHEMBL2587443 0.90 BCL2L1 (0.52) CA1CA2SMN1; SMN2PTPN1BCL2L1
Acetic Acid SCHEMBL27750535 0.87 SMN1; SMN2 (0.54) PDCD1CD274KDM4ELMNASMN1; SMN2
Acetic Acid SCHEMBL27275952 0.84 TSHR (0.40) PDCD1CD274CA12CA1CA2
SCHEMBL787166 0.84 TSHR (0.52) CA12CA1CA2CA9CA14
SCHEMBL689989 0.84 CA1 (0.54) CA12CA1CA2CA9CA14
SCHEMBL23082728 0.83 PARP10 (0.57) KDM4ESMN1; SMN2ALDH1A1
SCHEMBL2835113 0.83 CES2 (0.48) CA1CA2SMN1; SMN2PTPN1BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10042272-B2 Electrophotographic photosensitive member, method for producing the same, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2018-08-07 US disclosed
US-10042272-B2 Electrophotographic photosensitive member, method for producing the same, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2018-08-07 US disclosed
US-20170299971-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR PRODUCING THE SAME, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2017-10-19 US disclosed
US-20170299971-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR PRODUCING THE SAME, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2017-10-19 US disclosed