Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848025 | 0.81 | ERN1 (0.41) | GABRA1GABRB2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL20681233 | 0.80 | HMGCR (0.41) | GABRA1GABRB2LMNAMAPTHTT | |
| SCHEMBL30791023 | 0.78 | HMGCR (0.39) | GABRA1GABRB2LMNAMAPT | |
| Ammonia Solution, Strong SCHEMBL29178990 | 0.78 | HMGCR (0.39) | GABRA1GABRB2LMNAMAPT | |
| SCHEMBL10717222 | 0.78 | GABRA1 (0.34) | GABRA1GABRB2RIPK1 | |
| SCHEMBL30014250 | 0.78 | GABRA1 (0.34) | GABRA1GABRB2RIPK1 | |
| SCHEMBL17873619 | 0.78 | GABRA1 (0.55) | GABRA1GABRB2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL26200345 | 0.77 | AGTR1 (0.33) | GABRA1GABRB2 | |
| SCHEMBL469841 | 0.76 | GABRA1 (0.52) | GABRA1GABRB2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL456782 | 0.76 | GABRA1 (0.52) | GABRA1GABRB2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184604-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | IFM THERAPEUTICS, INC (US) | 2017-10-26 | — | — | WO | disclosed |